Flat soft drink and anticancer drug effectiveness

Wednesday, 27 October, 2010


Experiments with an artificial stomach suggest that a popular lemon-lime soft drink could play an unexpected role in improving the effectiveness of an oral anticancer drug. The experiments produced evidence that patients will absorb more of the unnamed drug, tested in Phase I in clinical trials, when taken with ‘flat’ or degassed Sprite.

The study appears in ACS’ Molecular Pharmaceutics.

Faraj Atassi and colleagues note that efforts are underway to develop more anticancer medications that patients can take by mouth. However, biological variations among patients - due to variations in stomach acidity and other factors - can reduce the effectiveness of oral anticancer drugs. Such was the case with the unnamed anticancer drug in the study, identified only as Compound X. There were wide differences in how the drug was absorbed in the first patients who took it.

The scientists combined Compound X with Captisol, a substance that helps improve the solubility of drug ingredients, and turned to the artificial stomach. That glass-and-plastic device is used to study how drugs and foods dissolve through the GI tract. They showed that Sprite seemed to control stomach acidity in a way likely to allow greater absorption of the drug into the body. Based on the results, the scientists suggest that patients in future clinical trials take the drug with Sprite.

Please note: this news item should not be construed as being medical advice.

Related News

Bush food: researching the green plum

Researchers from the University of Queensland are investigating the health benefits of the green...

Findings from romaine lettuce E. coli investigation in US

The FDA has released findings of an investigation into three US outbreaks of E. coli O157:H7...

Turning banana waste into food packaging

UNSW celebrates research that has uncovered a way to turn waste banana stalks into biodegradable...


  • All content Copyright © 2020 Westwick-Farrow Pty Ltd